Understanding Weight Loss Drugs
- Emily Simpson, of The Real Housewives of Orange County, has revealed that she uses a GLP-1 weight-loss medication to help “maintain” the 50 pounds she has lost.
- Semaglutide is a GLP-1 receptor agonist, meaning that it mimics the effects of GLP-1 in the body. Given as weekly subcutaneous injections, it is typically prescribed to manage blood glucose levels in patients with diabetes. It also leads to significant weight loss in these patients.
- Dr. Neil Iyengar tells SurvivorNet, “Diet, exercise, and lifestyle changes are essential for maintaining a healthy weight, but reaching that level of weight loss can be incredibly difficult for many. That’s why the discussion also includes tools like GLP-1 receptor agonists and bariatric surgery [weight loss surgery], which can help support the kind of significant weight loss associated with lowering cancer risk.”
- SurvivorNet’s sister site, SNWeightloss, provides a wide range of expert-driven resources on GLP-1 medications, including how they function, their potential uses, side effects, and emerging research that continues to offer hope for people managing weight loss while also potentially lowering cancer risk.
- If you’re considering taking a weight loss drug, talk with your care team about whether that’s a good option for you. And make sure you consider good diet and exercise practices as a part of your treatment plan.
- If you have questions you want answered. Check out SurvivorNet’s proprietary AI tool “My Health Questions”
Reality TV star Emily Simpson, a main cast member on Season 20 of The Real Housewives of Orange County has admitted to using a GLP-1 weight loss medication to “maintain” her 50-pound weight loss.
Speaking exclusively to Us Weekly magazine, Simpson, who often shares videos of herself working out on social media, said, “I do still [use a GLP-1, but] not much as I did. I use it now to just … maintain. So I’ll go a few weeks and not use it, and then I’ll feel like I’m starting to gain weight and then I’ll use it again.” Read MoreSimpson described her usage as “microdosing,” noting how she prioritizes weight maintenance.
She told the magazine that she has since lost 50 pounds and strives to lose another 10—however, she isn’t just relying on the medication to do so—she focuses on eating healthy portions.
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The mom of three said she “rarely” drinks alcohol, although she’ll occasionally enjoy a drink with dinner.
She also hasn’t eliminated any specific foods from her diet and still enjoys eating ice cream with her kids, saying, “It’s just in moderation.”
Simpson then recalled how she used to consume food “mindlessly,” especially food around her children.
“Now I’m just more conscientious of what I’m eating,” she added.
Alongside a recent video shared on Instagram, Simpson captioned her post, “I’ve never met a goal I couldn’t crush.”
She was seen doing pull-ups at the gym, lifting barbells overhead, and showing off her toned physique in glamorous dresses.
“You should be so proud of yourself…you worked so hard. You look amazing,” commented one fan.
Another wrote, “You’re a winner no matter what. I’m so proud of you bc it’s not easy.”
Simpson also shared a transformation video compilation, showing glimpses of herself in covered-up workout gear while riding an elevator, along with recent footage of her exercising in her bedroom in a bikini.
A third fan wrote, “You look amazing! I think I’m older than you, but we still come from the same general era. I’m always impressed when someone does what it really takes to live longer. You definitely DO NOT have an Ozempic body. Your body is clearly the result of hard consistent work. Well done!”
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Understanding GLP-1 Receptor Agonists & How They Work
GLP-1 receptor agonists (GLP-1RAs) are a group of medications primarily used to manage type 2 diabetes. They help lower blood sugar levels by mimicking a natural hormone that regulates insulin release and appetite.
It’s important to note that there are a variety of drugs available right now for weight loss, such as Novo Nordisk’s semaglutide — sold under the brand names Ozempic, Wegovy, and Rybelsus — and Eli Lilly’s tirzepatide — sold under the brand names Mounjaro and Zepbound.
Others include phentermine (Adipex-P, Lomaira), a prescription medication that reduces appetite; Contrave (naltrexone/bupropion); and bupropion (the generic form of Wellbutrin).
Additionally, an oral (pill) form of semaglutide is reaching a broader patient population after the FDA approved the pill in 2025.
GLP-1 RAs mimic a hormone your body naturally makes (called glucagon-like peptide-1) that helps regulate blood sugar and feelings of hunger. Initially developed to treat type 2 diabetes by lowering blood sugar levels, these medications were later found to have an impressive effect on appetite control. As a result, many people who take them lose significant amounts of weight.
“GLP-1 … is a hormone that is secreted in the L cells of the intestines, and we all make GLP-1 after we start to eat a meal,” Dr. Holly Lofton, Director of the Medical Weight Management Program at NYU Langone in Manhattan, previously told SurvivorNet.
“After food reaches the stomach, the stomach sends GLP-1 to the brain to sense hunger is no longer present and the person starts to feel more full. In the hypothalamus, specifically of the brain, once the brain receives that GLP-1, it sends a message to the person to stop eating.”
The native GLP-1 that our bodies make and the GLP-1 agonists go to the brain and block appetite signals, go to the stomach to help it empty more slowly, and help shrink fat cells, Dr. Lofton added.
And weight reduction is not the only effect these medications may have.
Researchers are learning that GLP-1 RAs could also influence other behaviors — such as smoking or alcohol use — and possibly reduce certain health risks that come with obesity. In fact, several large studies show that people taking GLP-1 RAs have better heart health, lower rates of kidney problems, and may even be less likely to develop some types of cancer.
Should You Consider a GLP-1 RA?
Deciding on a weight loss approach — whether it’s lifestyle modifications, medication, or surgery — is highly personal. Some points to consider with your healthcare team include:
- Your Overall Health: Do you have type 2 diabetes or other chronic conditions affected by weight? GLP-1 RAs can improve blood sugar control and lower cardiovascular risks, in addition to promoting weight loss.
- Cancer Risks: If you have a strong family history or other risk factors for obesity-related cancers, long-term medication use might offer extra benefits — but the evidence, while promising, is still growing.
- Commitment and Cost: These medications often need to be taken indefinitely to maintain weight loss. Make sure you feel comfortable with the potential side effects, follow-up visits, and ongoing costs.
- Alternatives: Bariatric surgery [weight loss surgery], structured lifestyle changes, and other treatments may also reduce cancer risk and help you lose weight. Talk with your doctor about which option is best suited to your overall health and personal goals.
GLP-1 receptor agonists are powerful tools in the fight against obesity. Emerging research suggests they may also help reduce the risk of certain cancers that are tied to excess weight, potentially to a degree that mirrors — or, in some aspects, surpasses — bariatric surgery. However, questions remain about long-term adherence, muscle loss, side effects, and whether the benefits persist after stopping the medication.
If you’re considering a GLP-1 RA, it’s crucial to have a thorough discussion with your healthcare provider about the benefits, risks, and costs of treatment. Together, you can map out a plan that helps you achieve healthier weight control, lowers your risk for certain obesity-related cancers, and enhances your overall well-being for the long run.
Weight Loss & Cancer Risk
It’s important to note that although Simpson has never battled cancer, researchers are continuing to uncover important connections between weight and cancer risk.
A study published in JAMA highlights the powerful connection between obesity and cancer: obesity is linked to roughly 10% of all new cancer diagnoses in the United States each year, and for certain cancer types, it may be a contributing factor in nearly half of all diagnoses.
For oncologists, the findings provide a more nuanced view of what counts as meaningful weight loss.
“One of the biggest takeaways from this paper is that people with classical obesity often need to lose more than 10% of their body weight to meaningfully reduce cancer risk,” Dr. Neil Iyengar, Associate Professor, Co-director of Breast Medical Oncology, and Director of Cancer Survivorship at Emory Winship Cancer Institute, tells SurvivorNet.
“Diet, exercise, and lifestyle changes are essential for maintaining a healthy weight, but reaching that level of weight loss can be incredibly difficult for many. That’s why the discussion also includes tools like GLP-1 receptor agonists and bariatric surgery [weight loss surgery], which can help support the kind of significant weight loss associated with lowering cancer risk.”
Iyengar is open to the idea of testing the effectiveness of GLP-1 agonists in oncology and figuring out how safe they are in battling cancer, previously telling SurvivorNet, “I don’t think that there’s mechanistically anything that’s particularly worrisome. GLP-1 agonists do a lot of things that we don’t fully understand yet.”
Dr. Samantha Newman, at Memorial Sloan Kettering Cancer Center, also spoke with SurvivorNet on this matter, explaining, “GLPs are amazing medications. They change people’s lives in terms of cardiac risk and diabetes. They have widespread benefits.”
WATCH: The Key Factors For Weight Loss On New Blockbuster Drugs
GLP-1 medications like Ozempic work through mechanisms that extend beyond the scale. Dr. Lofton points to a broad range of documented benefits.
“Some of the benefits for using GLP-1 agonists can be weight loss, improvement in glycemic control or blood glucose, decreased risk of weight-related conditions such as various cancers, like breast cancer, endometrial cancer, colon cancer, liver disease,” Dr. Lofton tells SurvivorNet.
The Centers for Disease Control and Prevention (CDC) says, “Being overweight or having obesity are linked with a higher risk of getting 13 types of cancer.”
WATCH: NYU’s Dr. Holly Lofton explains what we do know about GLP-1RAs and cancer risk
Research published in the journal “Cancers” says that “obesity also increases the risk of dying from cancer and may influence the treatment choices. About 4–8% of all cancers are attributed to obesity.”
Some of the cancers associated with being overweight or obese include:
- Colon
- Breast
- Ovarian
- Esophagus
- Pancreatic
- Multiple myeloma
- Endometrial
- Liver
WATCH: Living a healthy lifestyle.
According to the National Cancer Institute (NCI), fat tissue “produces excess amounts of estrogen,” which is associated with an increased risk of certain cancers, including breast, ovarian, and endometrial cancer. The NCI says a person who is severely obese is “7 times” more likely to be diagnosed with endometrial cancer.
Obesity is associated with high levels of insulin, which can lead to colon, kidney, prostate, and endometrial cancer.
Obesity can affect cancer survivors in various ways, including the chance of cancer recurrence and overall quality of life.
To learn more about your ideal healthy weight, determine your body mass index (BMI).
Body weight that exceeds what the body mass index deems appropriate for your weight and height can help determine body fat content. Although your BMI can help you learn if you are at a healthy weight, underweight, overweight, or obese, other factors may contribute to your overall health.
The NCI analyzed several studies to observe the impact of physical activity on overall cancer risk. The NCI says that “higher levels of physical activity are linked to lower risk of several types of cancer.”
Regular exercise, a balanced diet, and managing stress are some ways people can practice leading a healthy life. For cancer survivors, a healthier lifestyle alongside getting regular checks for recurrence may improve their quality of life.
Contributing: SurvivorNet Staff
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